Severe autoimmune hemolytic anemia during pegylated interferon plus ribavirin treatment for chronic hepatitis C: a case report
نویسندگان
چکیده
We report a rare case of severe autoimmune hemolytic anemia triggered by pegylated interferon during combination therapy for chronic HCV. This case demonstrated that interferon can de novo induce autoimmune hemolytic anemia during therapy for chronic hepatitis C in a previously healthy patient.
منابع مشابه
The Development of Cold-type Autoimmune Hemolytic Anemia during Peginterferon alfa-2a plus Ribavirin Treatment in Chronic Hepatitis C Patient: a Case Report
Peginterferon-alfa 2a or alfa 2b plus ribavirin is the treatment of choice in chronic hepatitis C. Severe adverse effects may compromise efficacy of this regiment. There are few reports of warm autoimmune hemolytic anemia following interferon-alfa or peginterferon-alfa2b plus ribavirin treatment. This present report discusses autoimmune hemolytic anemia which developed during peginterferon alfa...
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Two cases of autoimmune hemolytic anemia that occurred during the treatment of chronic hepatitis C with pegylated alpha-2a interferon and ribavirin, in HIV coinfected patients, are presented and described. The late occurrence (after six months of therapy) of this severe hemolytic anemia leads to the recommendation that hemoglobin levels should be monitored throughout the treatment period, even ...
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A 55-year-old Egyptian woman with chronic hepatitis C undergoing treatment with pegylated interferon (Peg-IFN) alfa-2a plus ribavirin was referred to our hospital on November 2010 with prolonged easy fatigability and an attack of syncope; she had no prior history of autoimmune disorders or allergy. Laboratory investigations documented the presence of Peg-IFN induced autoimmune haemolytic anaemi...
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Chronic hepatitis C virus (HCV) infection has been associated with various extrahepatic manifestations, including autoimmune cytopenias. Primary autoimmune haemolytic anaemia (AIHA) has been reported as an unusual extrahepatic manifestation. Combination therapy with pegylated interferon (PEG-IFN) and ribavirin (RBV) is the current treatment of choice for chronic HCV infection. However, this the...
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